Clinical Applications of Induced Sputum
نویسنده
چکیده
The author has reported to the ACCP that no significant conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article. Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal. org/misc/reprints.shtml). Correspondence to: Nancy A. Collop, MD, FCCP, Johns Hopkins University, Division of Pulmonary/CCM, Johns Hopkins University DOM, 1830 East Monument St, Room 555, Baltimore, MD 21205; e-mail: [email protected] DOI: 10.1378/chest.130.5.1625a
منابع مشابه
Induced Sputum for Assessment of Airway Inflammation in Patients with Copd, Asthma and Asthma-like Symptoms
.................................................................................................................. 9 INTRODUCTION ...................................................................................................... 10 REVIEW OF THE LITERATURE ........................................................................... 11 DEFINITIONS ................................................
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PURPOSE OF REVIEW Induced sputum is a particularly useful procedure since it provides information on the cellular and molecular constituents in inflammation. Extensive work has demonstrated the application of induced sputum in the management of asthma, chronic obstructive pulmonary disease and chronic bronchitis, but less attention has been paid to its efficacy in diagnosing interstitial lung d...
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1 Brightling CE. Clinical applications of induced sputum. Chest 2006; 129:1344–1348 2 Brightling CE. Chronic cough due to nonasthmatic eosinophilic bronchitis: ACCP evidence-based clinical practice guidelines. Chest 2006; 129(suppl):116S–121S 3 Melvin R. Pratter MR, Brightling CE, et al. An empiric integrative approach to the management of cough: ACCP evidence-based clinical practice guidelines...
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The development of standardized methods for sputum induction has improved the quality and reproducibility of sputum samples. This technique has been used to optimize samples in the investigation of pulmonary tuberculosis and lung cancer, but its clinical application as a noninvasive measure of airway inflammation has highlighted the enormous potential of this technique. Sputum induction has all...
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As asthma is considered to be an inflammatory disorder of the airways, it seems logical to include an assessment of this inflammatory process as an outcome measure in clinical trials. Biopsy studies illustrate that clinical or lung function characteristics such as symptoms, peak flow variability or degree of airway responsiveness do not consistently correlate with histological alterations. Ther...
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