Further characterization of a cattle nematode population with demonstrated resistance to current anthelmintics.

نویسندگان

  • Louis C Gasbarre
  • Larry L Smith
  • Eric Hoberg
  • Patricia A Pilitt
چکیده

We previously documented the appearance of cattle nematode parasites resistant to avermectins, milbemycin, and a benzimidazole at the end of a grazing season in a backgrounding operation in the upper Midwestern US. To further characterize the pattern of drug resistance, we extended the study to (1) monitor the animals over the course of the grazing season; (2) increase the number of animals slaughtered at the end of the season to minimize the effect of potential outlying observations; (3) increase the time interval between treatment and slaughter to ensure sufficient time for drug action; (4) utilize repeated fecal sampling in the fecal egg reduction test to minimize procedural variation; (5) increase the number of drugs tested. The results of the present study were in agreement with those of the previous study and demonstrated that during the course of the grazing season the pastures harbored significant numbers of parasites that were refractory to avermectins, milbemycin, and a benzimidazole at the label recommended doses. As seen previously, Haemonchus contortus resistant to all these anthelmintics were present over the course of the study period. In contrast, Cooperia sp., mainly punctata, and Haemonchus placei were resistant only to the macrocyclic lactones. There was no apparent resistance against the older anthelmintic levamisole, which had not been used for >20 years in the operation. However, animals treated with this drug continued to harbor small but measurable numbers of Ostertagia ostertagi.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Anthelmintic resistance of gastrointestinal cattle nematodes Anthelminthicumresistentie van gastro-intestinale rundernematoden

Anthelmintic resistance of parasites in small ruminants, cattle and horses is increasing worldwide as a consequence of the over usage of the currently available products. In Belgium, Cooperia oncophora is the most common cattle nematode in which resistance, especially against macrocyclic lactones, occurs. Once resistance has been diagnosed, a change to another drug with a different mode of acti...

متن کامل

Strongyle anthelmintic resistance in horses and cattle from Greece

Gastrointestinal nematode parasitism is an important cause of livestock disease, reduced productivity and welfare. In most cases, control of parasites is based on the use of anthelmintics or on the combination of anthelmintics and pasture management or recently, other alternatives to the use of chemicals. However, the frequent use of anthelmintics can select for resistant nematodes. Anthelminti...

متن کامل

The identification of cattle nematode parasites resistant to multiple classes of anthelmintics in a commercial cattle population in the US.

Resistance to modern anthelmintics by ruminant nematode parasites is an increasing problem throughout the world. To date the problem has largely been reported in parasites of small ruminants, but there are increasing reports of such resistance in nematodes recovered from cattle. Until now there have been no published reports of drug resistant parasites from cattle in North America. In 2002 a pr...

متن کامل

A Study of Sheep Nematode Populations on Ten Commercial Properties on Kangaroo Island, South Australia

South Australian studies to investigate the epidemiology of nematode parasites of sheep have been carried out at Kybybolite, Minnipa and Turretfield ( Brown et al. 1985; Pullman et al. 1988). The epidemiological differences between Kybybolite and Turretfield are being investigated further. Recently, resistance to major groups of anthelmintics has been detected in sheep nematode populations in S...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Veterinary parasitology

دوره 166 3-4  شماره 

صفحات  -

تاریخ انتشار 2009