Fibrinogen Gamma Chain Splice Variant γ′ alters Fibrin Formation and Structure
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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Fibrinogen gamma-chain splice variant alters fibrin formation and structure
Fibrinogen A/ results from alternative splicing of mRNA. This variant, which constitutes approximately 8% to 15% of plasma fibrinogen, contains FXIII and thrombin binding sites. Our objective was to investigate whether A/ differs in fibrin formation and structure from the more common variant A/ A. Both variants were separated and purified by anionexchange chromatography. Fibrin formation and cl...
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