A Short Communication On Kinetics of Antimicrobial Agents Release from Porous Collagen Scaffolds

Objective: Burst release of drugs occurs in a very short time compared to the entire sustained release process, yet it has not been specifically investigated in most of the work whereas our study aims the investigation of the burst release of antimicrobial agents from various collagen scaffolds and the release kinetics of antimicrobial agents from the collagen scaffolds. Materials and Methods: The extracted Type 1 Collagen from Bovine tendons is used for scaffold fabrication. The macro porous collagen scaffold is prepared by the CLRI protocol developed. The porous collagens scaffold is prepared by freeze drying method. Furthermore, the antimicrobial agents Triphala/Ciprofloxacin is physically conjugated and entrapment within the pores of the collagen scaffold. The in vitro release studies are carried out in Franz-type diffusion cells. The bacterial count in the granulation tissue is carried out in In Vivo studies. Results: The result concludes collagen dressings with burst release followed by controlled release effectively regenerate highly infected soft tissue. The collagen dressing provides burst release. Conclusion: To sum up, the collagen scaffold with burst release provides effective control of infection and better wound closure at the wound site. This investigation used to design the scaffold with burst release for eradication of infection and effective regeneration of skin at