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Referate – Abstracts – Analyses Physiology and Pathology of Blood Coagulation A Review of the Literature of 1950* (First Part) F. ROLLER, Zurich 1. General aspects. – 2. Prothrombin. – 3. Factor V (ac-globulin, labile factor). – 4. Thromboplastin. – 5. Platelets. – 6. Thrombín, antithrombin. – 7. Fibrinogen, fibrin. – 8. Heparin. – 9. Other anticoagulants. – 10. Thrombosis. -11. Hemophilia. 1. General Aspects Europe: Coagulation problems. Owren, P. A. Nord. Med. 24, 977 (1950). Riks-hospitalet, Oslo, Norway. A brief survey of recent advances in the field of coagulation is presented: 1. The active thromboplastin of the blood is due to cooperation between a throm-bocyte factor and one of plasmatic nature. 2. Factor V an inactive substance is activated during the coagulation process to form factor VI which accelerates the formation of thrombin. 3. Factor X helps’convert prothrombin into thrombin in the presence of factor VI, thromboplastin and calcium. The prothrombin content of the serum is elevated after spontaneous coagulation of the blood and subsides gradually within several days or weeks. Quick’s prothrombin consumption test fails to determine the prothrombin in the serum, due to the deficiency of factor X in the serum. 4. Prothrombin is thought to be a simple specific substance, not a complex of several factors as Quick suggests. It is converted into thrombin under the influence of an activator complex of intricate nature. Besides calcium, factor V and factor X, a thrombocyte factor and antihemophilic globulin are included in this complex. The author also suggests that the thrombocytes may contain the substance that effects the start of the entire coagulation process. Blutgerinnung und Aminosäuren. Hardy, E. et al. Z. exper. Med. 116, 412 (1950). Universitätsklinik, Heidelberg, Germany. Prothrombin time {Quick’s one-stage method) can be accelerated by adding certain amino acids. Données récentes sur la biochimie clinique de la coagulation sanguine. Jayle, M.F. Sem. Hop. Paris 26, 4190 (1950). * The following abstracts have been compiled from periodicals available and from reprints sent to us. The institute from which the paper originated was reported whenever its name was mentioned in the original article. In order to complete this list as well as possible we would greatly appreciate receiving reprints from the authors of papers on coagulation problems, as another series of abstracts under the same headings will be published in a later issue. The reprints should be addressed to the editor of these abstracts: Department of Medicine, Rantons-spital, Zurich. K o 11 e r ‚ Physiology and Pathology of Blood Coagulation 179 Coagulation du sang. Bernier, ].-]. Sem. Hop. Paris 26, 1450 (1950). A short survey of blood coagulation is given with addition of the newly established facts. Über Blutgerinnung und Gerinnungsfaktoren. Schultze, E. Klin. Wschr. 28, 241 (1950). Chem. Abtg. Behringwerke, Marburg a. d. Lahn, Germany.