Efficacy of pyrvinium pamoate against Cryptosporidium parvum infection in 1 vitro and in a neonatal mouse model 2 3 Running title : Inhibition of Cryptosporidium by pyrvinium 4 5 Autumn
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چکیده
* Corresponding author: David J. Sullivan. Mailing address: Department of Molecular 17 Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 18 615 N. Wolfe St., Baltimore, Maryland 21205, USA. Phone: (410) 502-2522, FAX: (410) 95519 0105. E-mail: [email protected] 20 21 22 23 A CE PT ED Copyright © 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.00207-08 AAC Accepts, published online ahead of print on 30 June 2008
منابع مشابه
Efficacy of pyrvinium pamoate against Cryptosporidium parvum infection in vitro and in a neonatal mouse model.
No effective approved drug therapy exists for Cryptosporidium infection of immunocompromised patients. Here we investigated the nonabsorbed anthelmintic drug pyrvinium pamoate for inhibition of the growth of the intestinal protozoan parasite Cryptosporidium parvum. The concentration of pyrvinium that effected 50% growth inhibition in human enterocytic HCT-8 cells by a quantitative alkaline phos...
متن کاملEfficacy of pyrvinium pamoate against Cryptosporidium parvum infection in 1 vitro and in a neonatal mouse model 2 3 Running title : Inhibition of
* Corresponding author: David J. Sullivan. Mailing address: Department of Molecular 17 Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 18 615 N. Wolfe St., Baltimore, Maryland 21205, USA. Phone: (410) 502-2522, FAX: (410) 95519 0105. E-mail: [email protected] 20 21 22 23 A CE PT ED Copyright © 2008, American Society for Microbiology and/or the Listed A...
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Purpose: The purpose of this study is to model Cryptosporidiosis in laboratory animals. The parasites were inoculated into animalsand thenmultiplied. The process of proliferation was compared to controlCryptosporidiosis in humans. Materials and Methods: Twenty-five laboratory mice (4-7 days of age) and twenty-five laboratory rats (5 days of age) were assigned to the category I while the cat...
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Cryptosporidium parvum is a zoonotic protozoan parasite with a wide range of vertebrate hosts. The present study was conducted to determine the prevalence of Cryptosporidium parvum in urban and rural dogs of the Ahvaz area. Faecal samples were collected randomly from 93 dogs between May 2005 and September 2007. The studied dogs were divided into two groups (urban and rural) and based on age int...
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