∆-1-Piperideine-6-carboxylate dehydrogenase, a new enzyme that forms α-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes
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چکیده
∆-1-Piperideine-6-carboxylate dehydrogenase, a new enzyme that forms α-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes Juan L. de la FUENTE*, Angel RUMBERO†, Juan F. MARTI;N*‡ and Paloma LIRAS*‡ *Area of Microbiology, Faculty of Biology, University of Leo! n, 24071 Leo! n, Spain, †Department of Organic Chemistry, Autonomous University of Madrid, 28049 Cantoblanco, Madrid, Spain, and ‡Institute of Biotechnology INBIOTEC, Avda. del Real, 1, 24006 Leo! n, Spain
منابع مشابه
pcd mutants of Streptomyces clavuligerus still produce cephamycin C.
Biosynthesis of cephamycin C in Streptomyces clavuligerus involves the initial conversion of lysine to alpha-aminoadipic acid. Lysine-6-aminotransferase and piperideine-6-carboxylate dehydrogenase carry out this two-step reaction, and genes encoding each of these enzymes are found within the cephamycin C gene cluster. However, while mutation of the lat gene causes complete loss of cephamycin pr...
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