Naloxone as an Antidote for Benzodiazepine: An Experimental and Clinical Study
نویسنده
چکیده
This s tudy evaluates the potential ant idote action of naloxone o n e x p e r i m e n t a l l y i n d u c e d d i a z e p a m a n d f l u n i t r a z e p a m (benzodiazepines) intoxication in dogs. I t s an t ido te effects is also evaluated in a clinical sample of 8 patients suffering from f lun i t razepam intoxication. T h e clinical f indings were suggestive of ari antagonist ic act ion of naloxone in f luni t razepam intoxication. I t was also found t h a t f luni t razepam exhibits a diff e r e n t pharmacolog ica l p rof i l e f r o m o t h e r m e m b e r s of t h e benzodiazepine group . O u r f indings of a selective naloxanef luni t razepam reversal need t o be explained in relat ion t o the mechanism of act ion of this benzodiazepine, a s well a s t o the e q u a t e d naloxane-opiates reversal. ( ~ g y p t . ~ . ~ s ~ c h i a t . , 1 9 9 2 , 1 5 :
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