Embryonic asymmetry: The left side gets all the best genes
نویسندگان
چکیده
The origin of left-right developmental asymmetry is a continuing puzzle, but some recent results provide new insights into the steps leading to organ asymmetry - implicating the homeobox protein Pitz-2 in one key step - and others support a model of symmetry-breaking that involves the chirality of microtubules.
منابع مشابه
Left-Right Asymmetry of Maturation Rates in Human Embryonic Neural Development.
BACKGROUND Left-right asymmetry is a fundamental organizing feature of the human brain, and neuropsychiatric disorders such as schizophrenia sometimes involve alterations of brain asymmetry. As early as 8 weeks postconception, the majority of human fetuses move their right arms more than their left arms, but because nerve fiber tracts are still descending from the forebrain at this stage, spina...
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Statement of Problem: In some cases, a difference in size between the right and left teeth, during band selection for first molars, is observed. Purpose: The aim of this study was to measure the mesiodistal width and to compare the teeth on left and right sides of jaws in individuals with normal occlusion, according to the sex. Materials and Methods: In this cross-sectional study, sixty student...
متن کاملA right-sided pathway involving FGF8/Snai1 controls asymmetric development of the proepicardium in the chick embryo.
The proepicardium (PE) is a transient structure that forms at the venous pole of the embryonic vertebrate heart. This cardiac progenitor cell population gives rise to the epicardium, coronary vasculature, and fibroblasts. In the chicken embryo, the PE displays left-right (L-R) asymmetry and develops only on the right side, while on the left only a vestigial PE is formed, which subsequently gets...
متن کاملSexually Dimorphic and Sex-Independent Left-Right Asymmetries in Chicken Embryonic Gonads
Female birds develop asymmetric gonads: a functional ovary develops on the left, whereas the right gonad regresses. In males, however, testes develop on both sides. We examined the distribution of germ cells using Vasa/Cvh as a marker. Expression is asymmetric in both sexes: at stage 35 the left gonad contains significantly more germ cells than the right. A similar expression pattern is seen fo...
متن کاملThe bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness.
dHAND and eHAND are basic helix-loop-helix transcription factors that play critical roles in cardiac development. The HAND genes have a complementary left-right cardiac asymmetry of expression with dHAND predominantly on the right side and eHAND on the left side of the looped heart tube. Here we show that although eHAND is asymmetrically expressed along the anterior-posterior and dorsal-ventral...
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ورودعنوان ژورنال:
- Current Biology
دوره 9 شماره
صفحات -
تاریخ انتشار 1999