Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion

نویسندگان

  • Srinika Ranasinghe
  • Pedro A. Lamothe
  • Damien Z. Soghoian
  • Samuel W. Kazer
  • Michael B. Cole
  • Alex K. Shalek
  • Nir Yosef
  • R. Brad Jones
  • Faith Donaghey
  • Chioma Nwonu
  • Priya Jani
  • Gina M. Clayton
  • Frances Crawford
  • Janice White
  • Alana Montoya
  • Karen Power
  • Todd M. Allen
  • Hendrik Streeck
  • Daniel E. Kaufmann
  • Louis J. Picker
  • John W. Kappler
  • Bruce D. Walker
چکیده

CD8+ T cell recognition of virus-infected cells is characteristically restricted by major histocompatibility complex (MHC) class I, although rare examples of MHC class II restriction have been reported in Cd4-deficient mice and a macaque SIV vaccine trial using a recombinant cytomegalovirus vector. Here, we demonstrate the presence of human leukocyte antigen (HLA) class II-restricted CD8+ T cell responses with antiviral properties in a small subset of HIV-infected individuals. In these individuals, T cell receptor β (TCRβ) analysis revealed that class II-restricted CD8+ T cells underwent clonal expansion and mediated killing of HIV-infected cells. In one case, these cells comprised 12% of circulating CD8+ T cells, and TCRα analysis revealed two distinct co-expressed TCRα chains, with only one contributing to binding of the class II HLA-peptide complex. These data indicate that class II-restricted CD8+ T cell responses can exist in a chronic human viral infection, and may contribute to immune control.

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عنوان ژورنال:

دوره 45  شماره 

صفحات  -

تاریخ انتشار 2016