Fungal DNA detected in blood samples of patients who received contaminated methylprednisolone injections reveals increased complexity of causative agents.
نویسندگان
چکیده
Using Exserohilum rostratum-specific and panfungal real-time PCR, we studied 24 blood samples and 2 synovial fluid specimens from 20 patients with persistent or worsening pain following injections of contaminated methylprednisolone. Seven blood specimens from 6 patients were significantly positive for fungal DNA by panfungal PCR, with multiple fungal species identified.
منابع مشابه
Vascular complications of fungal meningitis attributed to injections of contaminated methylprednisolone acetate.
IMPORTANCE Fungal meningitis due to injections of contaminated methylprednisolone acetate can present with vascular sequelae in immunocompetent individuals. This is particularly germane to neurologists because better recognition of the clinical characteristics of patients with fungal meningitis and ischemic stroke will provide more timely and efficient care. OBSERVATIONS In a case series, 3 p...
متن کاملDetection of fungal DNA in human body fluids and tissues during a multistate outbreak of fungal meningitis and other infections.
Exserohilum rostratum was the major cause of an outbreak of fungal infections linked to injections of contaminated methylprednisolone acetate. Because almost 14,000 persons were exposed to product that was possibly contaminated with multiple fungal pathogens, there was unprecedented need for a rapid throughput diagnostic test that could detect both E. rostratum and other unusual agents of funga...
متن کاملFungal meningitis due to contaminated epidural steroid injections.
In the fall of 2012, as we finalized this issue of , an unprecedented outbreak of fungal meningitis occurred that was caused by contaminated preservative-free methylprednisolone acetate solution from the New England Compounding Center used in epidural steroid injections in thousands of patients. The predominant pathogen was found to be Exserohilum rostratum (a black mold). Aspergillus fumigatus...
متن کاملSpinal and Paraspinal Fungal Infections Associated With Contaminated Methylprednisolone Injections
BACKGROUND A nationwide outbreak of fungal infections was traced to injection of Exserohilum-contaminated methylprednisolone. We describe our experience with patients who developed spinal or paraspinal infection after injection of contaminated methylprednisolone. METHODS Data were assembled from the Michigan Department of Community Health, electronic medical records, and magnetic resonance im...
متن کاملMagnetic resonance imaging screening to identify spinal and paraspinal infections associated with injections of contaminated methylprednisolone acetate.
IMPORTANCE Injection of contaminated methylprednisolone has resulted in an unprecedented nationwide outbreak of Exserohilum rostratum fungal infections, manifested initially as meningitis and/or basilar stroke. Insidious onset of spinal or paraspinal infection at the injection site has been increasingly reported and is occurring months after receipt of injection with the contaminated drug. The ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of clinical microbiology
دوره 52 6 شماره
صفحات -
تاریخ انتشار 2014