The Use of Fatty Acid Supplementation for Seizure Management
نویسندگان
چکیده
importance of essential fatty acids (FA) for many physiological and behavioral mechanisms, in both humans and animals. In humans, essential fatty acids must be supplied via the diet. The genesis, maintenance, exacerbation, and treatment for many chronic health conditions are often related to deficiencies in omega-6 (linoleic acid) and omega-3 (alpha-linolenic acid), and their derivatives. In animal studies, providing supplementation of these FA changes chemical, immune, and structural properties of the brain, including the fluidity of the neuronal membrane. Of particular interest to epilepsy, pretreatment of a ratio of the FA omega-3 / omega-6 resulted in altering the threshold for seizures following administration of convulsant agents that reliably induce epileptic activity. This report reviews the human and animal clinical and experimental data and theoretical considerations that support the promise for FA supplementation for use by seizure patients.
منابع مشابه
Does Omega-3 Fatty Acid Supplementation Have Beneficial Effects on Plasma Homocysteine, Insulin Resistance and Lipid Profile of Type 2 Diabetic Patients? A Randomized Clinical Trial
Background: This study was conducted to determine the effects of n-3 PUFAs supplementation on plasma homocysteine (Hcy) level, lipid profile and insulin resistance in patients with type 2 diabetes (T2D). Methods: This study is a double-blind controlled trial involving 70 patients with T2D selected from Yazd Diabetes Research Center in 2013. Patients were randomly assigned to receive either 2 g/...
متن کاملChronic omega-3 supplementation in seizure-prone versus seizure-resistant rat strains: a cautionary tale.
Several studies have shown fatty acid supplementation to be efficacious in the treatment of attention deficit hyperactivity disorder/autism spectrum disorder (ADHD/ASD) and epilepsy. Interestingly, rats bred to be seizure-prone (Fast), unlike those bred for seizure-resistance (Slow), naturally exhibit behaviors and physiology reminiscent of ADHD/ASD in humans, suggesting a fundamental link betw...
متن کاملEffects of Fish Oil Supplementation during the Suckling Period on Auditory Neural Conduction in n-3 Fatty Acid-Deficient Rat Pups
Abstract Introduction: Omega 3 fatty acid especially in the form of fish oil, has structural and biological role in the body's various systems especially nervous system. Numerous studies have tried to research about it. Auditory is one of the affected systems. Omega 3 deficiency can have devastating effects on the nervous system and auditory. This study aimed to evaluate neural conduction in n-...
متن کاملEffect of diets with different levels of soybean meal and Kemin multi-enzyme on growth performance, body composition, and gut lactic acid bacteria of juvenile Beluga (Huso huso)
In this study, the effects of replacing fish meal with soybean meal on growth performance, feed efficiency, body composition, fatty acid profile and gut lactic acid bacteria of beluga sturgeon, Huso huso. Nine diets were formulated (40% crude protein) in which soybean meal was replaced by fish meal at 0 (control), 40 and 80% supplemented and with three multi-enzyme level 0, 1 or 2 g/kg of Kemin...
متن کاملIs omega-3 fatty acid deficiency a factor contributing to refractory seizures and SUDEP? A hypothesis
Epilepsy, the commonest serious neurological condition, is associated with an increased risk in premature deaths, including an estimated 500 sudden unexpected deaths (SUDEP) per year in the UK. In some patients seizures are associated with cardiac arrhythmias, which are thought to be a major factor in SUDEP. Omega-3 fatty acids have been shown to reduce cardiac arrhythmias in animal studies and...
متن کامل