Intraneuronal filamentous tau protein and alpha-synuclein deposits in neurodegenerative diseases.
نویسندگان
چکیده
Alzheimer's disease and Parkinson's disease are the most common neurodegenerative disorders of the human brain. They are characterized by the presence of ordered filamentous assemblies which gradually develop in a small number of nerve cell types. I n Alzheimer's disease, vulnerable nerve cells develop neurofibrillary tangles, neuropil threads and abnormal neurites, whereas in Parkinson's disease they develop Lewy bodies and Lewy neurites (reviewed in [1,2]). Alz-heimer's disease is characterized by the additional presence of extracellular deposits in the form of amyloid plaques. Over recent years, it has become clear that the intraneuronal filamentous deposits of Alzheimer's disease and Parkinson's disease are composed of tau protein and a-synu
منابع مشابه
Initiation and synergistic fibrillization of tau and alpha-synuclein.
Alpha-synuclein (alpha-syn) and tau polymerize into amyloid fibrils and form intraneuronal filamentous inclusions characteristic of neurodegenerative diseases. We demonstrate that alpha-syn induces fibrillization of tau and that coincubation of tau and alpha-syn synergistically promotes fibrillization of both proteins. The in vivo relevance of these findings is grounded in the co-occurrence of ...
متن کاملIdentification of G-protein coupled receptor kinase 2 in paired helical filaments and neurofibrillary tangles.
G-protein coupled receptor kinases (GRKs) constitute a serine/threonine kinase family playing a major role in agonist-induced phosphorylation and desensitization of G-protein coupled receptors. Recently, GRK2 and GRK5 have been demonstrated to phosphorylate alpha-synuclein (Ser129) and other synuclein isoforms. We studied colocalization of GRK2, GRK5, alpha-synuclein, and tau in neurodegenerati...
متن کاملSeeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases.
The deposition of amyloid-like filaments in the brain is the central event in the pathogenesis of neurodegenerative diseases. Here we report cellular models of intracytoplasmic inclusions of α-synuclein, generated by introducing nucleation seeds into SH-SY5Y cells with a transfection reagent. Upon introduction of preformed seeds into cells overexpressing α-synuclein, abundant, highly filamentou...
متن کاملAlpha-synuclein induced apoptosis and proliferation interacted with CD44 in human lymphocytes
Human ?-synuclein is a 140 amino acid protein with little or no secondary structure. The ?-synuclein is expressed at high levels in the brain and enriched in neural synaptic terminals but its physiological function remains largely unknown. More recently, ?-synuclein has been shown to be one of the principal componets of Lewy bodies, neuronal inclusions that are found in diverse human neurodegen...
متن کاملAlpha-synuclein induced apoptosis and proliferation interacted with CD44 in human lymphocytes
Human ?-synuclein is a 140 amino acid protein with little or no secondary structure. The ?-synuclein is expressed at high levels in the brain and enriched in neural synaptic terminals but its physiological function remains largely unknown. More recently, ?-synuclein has been shown to be one of the principal componets of Lewy bodies, neuronal inclusions that are found in diverse human neurodegen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Biochemical Society transactions
دوره 26 3 شماره
صفحات -
تاریخ انتشار 1998