In vitro activity of a new antibiotic, NVP-PDF386 (VRC4887), against Chlamydia pneumoniae.

نویسندگان

  • Patricia M Roblin
  • Margaret R Hammerschlag
چکیده

The in vitro activity of NVP-PDF386 (VRC4887), a novel new peptide deformylase inhibitor, and those of levofloxacin and clarithromycin were tested against 21 isolates of Chlamydia pneumoniae. The MIC at which 90% of the isolates were inhibited and the minimal bactericidal concentration at which 90% of the isolates were killed by NVP-PDF386 for all isolates of C. pneumoniae were 0.008 micro g/ml (range, 0.008 to 0.015 micro g/ml) compared to 0.25 and 0.06 micro g/ml for levofloxacin and clarithromycin, respectively.

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منابع مشابه

Comparative spectrum and activity of NVP-PDF386 (VRC4887), a new peptide deformylase inhibitor.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 47 4  شماره 

صفحات  -

تاریخ انتشار 2003