Anti-Parkinson’s and Neuroprotective Activity of Mentha Aquaticain 6- Hydroxy Dopamine Lesioned Rat Model

Objective: Menthaaquatica, plant which is showing monoamine oxidase-B (MAO-B) inhibition and antioxidant activity was assessed for anti-Parkinson’s activity in 6-hydroxy dopamine (6-OHDA) lesionedwistar rat model. Materials and Method: Menthaaquaticaethanolextract (EMA) was obtained by using alcoholic solvent. Acute oral toxicity of Menthaaquaticaextract was carried out in wistar rats. Rats were treated with 6-hydroxy dopamine (2μg/μl) intra nigrally. After 48 hrs of induction, extract of Menthaaquatica (200 mg/kg/day, p.o.) was given to the treatment groups for 60 days. Levodopa (6mg/kg) was used as the standard drug. The possible pharmacological actions of the plant extract was evaluated by anti-catatonic activity, striatal dopamine (DA) levels, mitochondrial complex-I activity and Superoxide dismutase (SOD) assay. Result: Menthaaquatica ethanol extract significantly (P<0.001) improved the muscle coordination, striatal dopamine level, complex-I activity and Superoxide dismutase level compare with 6-OHDA control group. Conclusion: Menthaaquatica ethanol extract produced a significant anti-Parkinson’s activity at a dose of 200mg/kg against 6-OHDA induced neurotoxicity.