Antibody Repertoires and Pathogen Recognition: the Role of Germline Diversity and Somatic Hypermutation
نویسنده
چکیده
of Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Computer Science The University of New Mexico Albuquerque, New Mexico
منابع مشابه
Trends in antibody sequence changes during the somatic hypermutation process.
Probable germline gene sequences from thousands of aligned mature Ab sequences are inferred using simple computational matching to known V(D)J genes. Comparison of the germline to mature sequences in a structural region-dependent fashion allows insights into the methods that nature uses to mature Abs during the somatic hypermutation process. Four factors determine the residue type mutation patt...
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To date, there has been no systematic study of the process of affinity maturation of human antibodies. We therefore sequenced the variable region genes (V genes) of 14 human monoclonal antibodies specific for the erythrocyte Rh(D) alloantigen and determined the germline gene segments of origin and extent of somatic hypermutation. These data were correlated with determinations of antibody affini...
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