Haplotype Inference for the Phase I HapMap
نویسنده
چکیده
We split each autosome in to non-overlapping segments of 80 SNPs and a new version of PHASE (v2.1) that deals with father-mother-child trios was applied to each segment in turn. We used the default settings of PHASE and took the most likely haplotype reconstruction returned by the program as the infered haplotypes. To link the haplotypes from each segment back together we used the information at non-ambiguous sites in each trio to infer the transmission status of each parental haplotype. That is, for each parent we worked out which haplotype was transmitted to the child and which haplotype was untransmitted. For each trio
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