NPM1 gene deletions in myelodysplastic syndromes with 5q- and complex karyotype.

نویسندگان

  • Emanuele Ammatuna
  • Paola Panetta
  • Xabier Agirre
  • Tiziana Ottone
  • Serena Lavorgna
  • Maria José Calasanz
  • Francesco Lo-Coco
چکیده

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NPM1 Deletion Is Associated with Gross Chromosomal Rearrangements in Leukemia

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Biological and prognostic significance of chromosome 5q deletions in myeloid malignancies.

The presence of del(5q), either as the sole karyotypic abnormality or as part of a more complex karyotype, has distinct clinical implications for myelodysplastic syndromes (MDS) and acute myeloid leukemia. The 5q- syndrome, a subtype of low-risk MDS, is characterized by an isolated 5q deletion and <5% blasts in the bone marrow and can serve as a useful model for studying the role of 5q deletion...

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Submicroscopic deletions in 5q- associated malignancies.

BACKGROUND AND OBJECTIVES The deletion of the long arm of chromosome 5 is common in myelodysplastic syndromes (MDS) but is not limited to the 5q- syndrome as it is also seen in acute myeloid leukemia (AML), where it is often associated with other karyotypic aberrations. The aim of this study was to investigate whether deletions of known suppressor sequences occur in myeloid malignancies associa...

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Fluorescence in situ hybridization improves the detection of 5q31 deletion in myelodysplastic syndromes without cytogenetic evidence of 5q-.

BACKGROUND More than 50% of patients with myelodysplastic syndromes present cytogenetic aberrations at diagnosis. Partial or complete deletion of the long arm of chromosome 5 is the most frequent abnormality. The aim of this study was to apply fluorescence in situ hybridization of 5q31 in patients diagnosed with de novo myelodysplastic syndromes in whom conventional banding cytogenetics study h...

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Higher Risk Myelodysplastic Syndromes in Patients with Well-Controlled HIV Infection: Clinical Features, Treatment, and Outcome

Introduction. In advanced HIV prior to combination antiretroviral therapy (ART), dysplastic marrow changes occurred and resolved with ART. Few reports of myelodysplastic syndromes (MDS) in well-controlled HIV exist and management is undefined. Methods. Patients with well-controlled HIV and higher risk MDS were identified; characteristics, treatment, and outcomes were reviewed. Results. Of 292 M...

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عنوان ژورنال:
  • Haematologica

دوره 96 5  شماره 

صفحات  -

تاریخ انتشار 2011