Combination therapy with galantamine and memantine improves behavioral and psychological symptoms of dementia (BPSD) in patients with early-onset Alzheimer's disease.
نویسنده
چکیده
Combination therapy with galantamine and memantine improves Behavioral and Psychological Symptoms of Dementia (BPSD) in patients with early-onset Alzheimer’s disease Atsushi Hamuro 天久台病院 精神科[〒 900-0005 沖縄県那覇市天久 1123] Amekudai Hospital, Department of Psychiatry (1123 Ameku, Naha, Okinawa 900-0005, Japan) (池嶋,朝田,2010).EOADと 65歳を超えて発症 する老年期のアルツハイマー型認知症は,病理所見 で老人斑と神経原線維を主に有するという点で同じ であるが,臨床症状,遺伝背景の違いも示唆されて いる.また介護負担もより多大でかつ,薬物療法も 困難であることが多い (中村,2010). わが国において新規の抗認知症薬は発売されて 1 年以上経過するが,著者が調べる限り EOADでみ られる行動・心理症状(以下,Behavioral and Psychological Symptoms of Dementia ; BPSDと記す)に, これらの抗認知症薬のみで調整が可能であった報告 は知らない.今回著者は,抗認知症薬のうちメマン チンとガランタミンの併用で EOADに見られる BPSDが軽減した症例を経験したので報告する.な お本研究の発表について本人と家族に説明し,文書 で同意を得た.
منابع مشابه
Two cases of Alzheimer’s disease showing deterioration of behavioral and psychological symptoms of dementia induced by switching from rivastigmine to donepezil
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ورودعنوان ژورنال:
- The Australian and New Zealand journal of psychiatry
دوره 47 6 شماره
صفحات -
تاریخ انتشار 2013