Determination of Myocardial Function Using Heart Accumulated Radiopharmaceuticals
نویسندگان
چکیده
The myocardium is composed of specialized muscle which relies mainly on fatty acid and sugar metabolism and it is widely contribute to the heart functioning. The changes of the cardiac energy-producing system during heart failure have been proved using autoradiography techniques. This study focused on evaluating sugar and fatty acid metabolism in myocardium as cardiac energy getting system using heart-accumulated radiopharmaceuticals. Two sets of autoradiographs of heart cross sections of Lewis male rats were analyzed and the timeaccumulation curve obtained with use of the MATLAB image processing software to evaluate fatty acid and sugar metabolic functions. Keywords—Autoradiographs, fatty acid, radiopharmaceuticals and sugar.
منابع مشابه
The Effect of Aerobic Training on expression of some indices of myocardial hypertrophy and atrophy in rats
Background: Protein synthesis and degradation are dynamically regulated processes that to control the accretion or loss of muscle mass. However, the mechanisms responsible exercise-induced heart hypertrophy remains elusive. The aim of this study was to investigate the effect of aerobic training on expression of some indices of myocardial hypertrophy and atrophy in male rats. Materials and Meth...
متن کاملProduction and quality control of 82mRb and primary PET scans using its radiopharmaceutical for heart examinations [Persian]
According to the importance of positron emitters in nuclear medicine, 82mRb was produced as a member of this group of radiopharmaceuticals. After being converted into an injectable form, enough information was provided for imaging with this radiopharmaceutical. 82mRb with high radioisotopic purity and half-life of 6.5 hours, in chloride form, can be considered as a suitable positron emitt...
متن کاملThe Status of Stress Myocardial Perfusion Imaging Using 99mTc Pharmaceuticals in Japan: Results from a Nationwide Survey
Objective(s): To appropriately use one-day myocardial perfusion imaging (MPI) with 99mTc radiopharmaceuticals (i.e. to avoid shine-through artifacts), injection doses need to be optimized and dose ratios between the 1st and 2nd scans should be maintained at ≥ 3. However, the current state of practice in Japan is unclear. Thus, the aim of this study was to clarify the details of MPI protocols us...
متن کاملEvaluation of Cardiac Mitochondrial Function by a Nuclear Imaging Technique using Technetium-99m-MIBI Uptake Kinetics
Mitochondria play an important role in energy production for the cell. The proper function of a myocardial cell largely depends on the functional capacity of the mitochondria. Therefore it is necessary to establish a novel and reliable method for a non-invasive assessment of mitochondrial function and metabolism in humans. Although originally designed for evaluating myocardial perfusion, 99mTc...
متن کاملADVANCES IN NUCLEAR MEDICINE- NUCLEAR CARDIOLOGY DR. VIKRAM R LELE Abstract: Nuclear cardiology is an extremely important modality in the management of coronary artery
Nuclear cardiology is an extremely important modality in the management of coronary artery disease. Information about myocardial perfusion , myocardial function, myocardial metabolism, myocardial innervation, myocardial infarction and apoptosis , atherosclerosis and gene therapy can be obtained with nuclear cardiology scans.Nuclear cardiology involves use of radiopharmaceuticals to study the fu...
متن کامل