Preferential Nuclear Accumulation of Jak 2 V 617 F in Cd 34 + but Not in Granulocytic , Megakaryocytic or Erythroid Cells of Patients With
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Thrombopoietin does not induce lineage-restricted commitment of Mpl-R expressing pluripotent progenitors but permits their complete erythroid and megakaryocytic differentiation.
In this study, we examined the in vitro and in vivo effects of forced expression of Mpl-R (the thrombopoietin receptor) on the progeny of murine hematopoietic stem cells. Bone marrow cells from 5-FU-treated mice were transduced with retroviral vectors containing the human Mpl-R cDNA, or the neomycine gene as a control. After 7 days cocultivation on virus-producer cells, GpE86-Mpl-R or Gp86-Neo,...
متن کاملRange Determination of Antigen Expression in Myeloid, Erythroid and Lymphoid Cell Lineages among Patients with Myelodysplastic Syndrome
Background: Myelodysplastic syndrome is a mixed clonal disorder of bone marrow progenitor cells. Understanding the pattern of the different lineage-specific, immature, and mature markers in myelodysplastic syndrome will help in setting-up the frame of reference to diagnose. Patients and Methods: We compared 60 bone marrow samples from 30 newly-diagnosed patients with myelodysplastic syndrome ...
متن کاملReceptor tyrosine kinase, EphB4 (HTK), accelerates differentiation of select human hematopoietic cells.
EphB4 (HTK) and its ligand, ephrinB2, are critical for angiogenesis and result in fatal abnormalities of capillary formation in null mice. EphB4 was originally identified in human bone marrow CD34(+) cells by us and has since been reported to be expressed in erythroid progenitors, whereas the ligand ephrinB2 is expressed in bone marrow stromal cells. Reasoning that the developmental relationshi...
متن کاملبررسی بیان ژن های موثر در سنتز گاما گلوبین قبل و بعد از تمایز سلول های بنیادی خونساز به رده سلول های اریتروئیدی
Background and aim: Induction of fetal hemoglobin (Hb-F) can improve the patients’ symptoms of haemoglobinopathies. Several factors can induce gamma globin gene expression and increased Hb-F levels in patients. In this study, the expression of genes is involved in regulation of gamma globin synthesis such as PIPKII-alpha BCL11a, and miR-30a during CD34+ hematopoietic stem cell differentiation i...
متن کاملبررسی شکل منحنی جریان و حجم در ضایعات انسدادی کارینا و برونش
Spirometry and flow - volume loop show the abnormal pattern of pulmonary dysfunction and the site of the obstruction of upper and peripheral airways. For determinig the shape of flow - volume loop in obstruction of carina and bronchus we examined 19 patients with large airway obstruction documented with fiberoptic bronchoscopy via pulmonary function testing and flow volume loop performing. Two...
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