Editorial: Cellular and Phenotypic Plasticity in Cancer
نویسندگان
چکیده
1 Oncogenic Signalling and Growth Control Program and Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia, 2 The Sir Peter MacCallum Department of Oncology, The University of Melbourne, East Melbourne, VIC, Australia, 3 Cancer Immunobiology, Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, Australia, 4 School of Cancer Medicine, La Trobe University, Heidelberg, VIC, Australia, 5 Metastasis Research Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia, 6 Institute of Health and Biomedical Innovation and School of Biomedical Sciences,
منابع مشابه
The phenotypic plasticity of the aquatic invertebrate Caenis latipennis in response to environmental conditions in the Kheirood Kenar River, Iran
Phenotypic plasticity is the capability of an organism to change its shape in response to the environmental condition. The present study aimed to investigate the phenotypic plasticity of the aquatic invertebrate Caenis latipennis using outline analysis. Samples were collected from up- and downstream of the Kheirood Kenar River, identified to the species level and photographed using a digital ca...
متن کاملThe effect of food type on phenotypic plasticity of sword tail, Xiphophurus helleri, during early ontogeny
Phenotypic plasticity is an important mechanism of phenotypic adaptation in response to environmental conditions. This study was conducted to investigate the effect of food type on the body shape of swordtail, Xiphoohurus helleri, during early development using geometric morphometric method. For this purpose, two treatments including feed by Artemia naupli and commercial Biomar diet were used i...
متن کاملCancer cells exhibit clonal diversity in phenotypic plasticity
Phenotypic heterogeneity in cancers is associated with invasive progression and drug resistance. This heterogeneity arises in part from the ability of cancer cells to switch between phenotypic states, but the dynamics of this cellular plasticity remain poorly understood. Here we apply DNA barcodes to quantify and track phenotypic plasticity across hundreds of clones in a population of cancer ce...
متن کاملReprogramming to developmental plasticity in cancer stem cells.
During development and throughout adult life, sub-populations of cells exist that exhibit phenotypic plasticity - the ability to differentiate into multiple lineages. This behaviour is important in embryogenesis, is exhibited in a more limited context by adult stem cells, and can be re-activated in cancer cells to drive important processes underlying tumour progression. A well-studied mechanism...
متن کاملThe overshoot and phenotypic equilibrium in characterizing cancer dynamics of reversible phenotypic plasticity.
The paradigm of phenotypic plasticity indicates reversible relations of different cancer cell phenotypes, which extends the cellular hierarchy proposed by the classical cancer stem cell (CSC) theory. Since it is still questionable if the phenotypic plasticity is a crucial improvement to the hierarchical model or just a minor extension to it, it is worthwhile to explore the dynamic behavior char...
متن کامل