Distinct but complementary contributions of PPAR isotypes to energy homeostasis.
نویسندگان
چکیده
Peroxisome proliferator-activated receptors (PPARs) regulate energy metabolism and hence are therapeutic targets in metabolic diseases such as type 2 diabetes and non-alcoholic fatty liver disease. While they share anti-inflammatory activities, the PPAR isotypes distinguish themselves by differential actions on lipid and glucose homeostasis. In this Review we discuss the complementary and distinct metabolic effects of the PPAR isotypes together with the underlying cellular and molecular mechanisms, as well as the synthetic PPAR ligands that are used in the clinic or under development. We highlight the potential of new PPAR ligands with improved efficacy and safety profiles in the treatment of complex metabolic disorders.
منابع مشابه
Distinct but complementary contributions of PPAR isotypes to energy homeostasis
Introduction Metabolic syndrome (MetS) is a pathophysiologic condition characterized by increased visceral adiposity, dyslipidemia, prediabetes, and hypertension. This cluster of risk factors predisposes to type 2 diabetes (T2D) and nonalcoholic fatty liver disease (NAFLD) and increases the risk of microvascular complications and cardiovascular (CV) events. With the global increase in obesity, ...
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 127 4 شماره
صفحات -
تاریخ انتشار 2017