Fungicidal activity of truncated analogues of dihydrosphingosine.

نویسندگان

  • Karin Thevissen
  • Ulrik Hillaert
  • Els M K Meert
  • Kuen K Chow
  • Bruno P A Cammue
  • Serge Van Calenbergh
  • Isabelle E J A François
چکیده

The minimal fungicidal concentration (MFC) of dihydrosphingosine (DHS), phytosphingosine (PHS), and five short-chain DHS derivatives was determined for Candida albicans and Candida glabrata. In this respect, a C15- and a C17-homologue of DHS showed a 2- to 10-fold decreased MFC as compared to native DHS (i.e. C18-DHS). DHS derivatives that were active, that is, comprising 12, 15, 17, or 18 carbon atoms, induced accumulation of reactive oxygen species (ROS) in C. albicans.

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عنوان ژورنال:
  • Bioorganic & medicinal chemistry letters

دوره 18 13  شماره 

صفحات  -

تاریخ انتشار 2008