A comparison of changes in the nucleus basalis and locus caeruleus in Alzheimer's disease.
نویسندگان
چکیده
In 22 patients with Alzheimer's disease loss of neurons from the nucleus basalis of Meynert and locus caeruleus averaged 58% and 71% respectively with nucleolar volume being reduced by 30% in both. These changes were greater in those patients under 80 years of age and in such patients damage to the locus was more severe than that to the nucleus basalis. In older patients (over 80 years) changes were similar in extent in both regions.
منابع مشابه
A comparison of nerve cell loss in cortical and subcortical structures in Alzheimer's disease.
Loss of nerve cells from temporal cortex, hippocampus, nucleus basalis of Meynert and locus caeruleus was measured in 32 patients with Alzheimer's disease ranging from 48 to 92 years of age. Similar changes were present within the cerebral cortex and within the two subcortical structures.
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ورودعنوان ژورنال:
- Journal of neurology, neurosurgery, and psychiatry
دوره 47 2 شماره
صفحات -
تاریخ انتشار 1984