Compliance with the peritoneal dialysis prescription is poor.

T he adequacy of peritoneal dialysis in terms of urea and creatinine kinetics is becoming better established (1 ,2). Weekly creatinine clearance of more than 50 L normalized to body surface area are currently recommended for minimally adequate dialysis. The delivery of an adequate peritoneal dialysis prescription is dependent on the compliance of the patient with that prescription. Keen et at. (3) have found overall compliance with prescribed exchanges in continuous ambulatory peritoneal dialysis to be only 78% . The purpose of this study was to determine the compliance of a group of patients on peritoneal dialysis through the use of creatinine generation rates. The utility of measured creatinine generation compared with estimated creatinine production depends on whether the patient is in the steady state while dialysate and urine are collected for analysis. Appreciating the overall compliance of peritoneal dialysis patients may alter the way in which it is prescribed.