Importance of Solid L ipid Nanoparticles in Cancer Therapy
ثبت نشده
چکیده
A BST R A C T A drug delivery system can be defined as a system that capable of releasing a carried bioactive agents in a specific location within the body at a specific rate. Anticancer drugs can be associated with colloidal carrier systems such as polymeric micelles, nanocapsules, liposomes and solid lipid nanoparticles, which can be actively targeted to specific tumor cell. The treatment of cancer is based on the delivery method. The cancer patients are using various anticancer drugs but these are less effective and have major side effects. Solid lipid nanoparticles (SLNs) have been introduced as an alternative drug carrier system to drug delivery. Due to the disadvantages of the other colloidal carriers (liposomes, emulsions, and polymeric microand nanoparticles), SLN developed. In this study, we determined how SLN can be used for cancer therapy. As a result, substances which have anti-cancer properties loaded SLN formulations were significantly more effective than free substances on cancer therapy. K eywords: Drug Delivery Systems, SLNs, Cancer Therapy.
منابع مشابه
Effects of Caffeic Acid Incorporated into Solid L ipid Nanoparticles in Cancer Cells
Nanotechnology has great potential to make an important role in prevention of cancer, detection, diagnosis, imaging and treatment. Solid lipid nanoparticles (SLNs) have been introduced as an alternative drug carrier system. Some of the features of SLN include good tolerability, site-specific targeting, stability, high drug payload, controlled drug release. Caffeic acid (CA) is a widespread phen...
متن کاملThe application of titanium dioxide (TiO2) nanoparticles in the photo-thermal therapy of melanoma cancer model
Objective(s): Photo-thermal therapy (PTT) is a therapeutic method in which photon energy is converted into heat to induce hyperthermia in malignant tumor cells. In this method, energy conversion is performed by nanoparticles (NPs) to enhance induced heat efficacy. The low-cytotoxicity and high optical absorbance of NPs used in this technique are very important. In the present study, titanium di...
متن کاملA systematic review of gold nanoparticles as novel cancer therapeutics
Objective(s):The current systematic study has reviewed the therapeutic potential of gold nanoparticles as nano radiosensitizers for cancer radiation therapy. Materials and Methods: This study was done to review nano radiosensitizers. PubMed, Ovid Medline, Science Direct, SCOPUS, ISI web of knowledge, Springer databases were searched from 2000 to September 2013 to identify appropriate studies....
متن کاملTruncated Hepatitis B virus like nanoparticles: A novel drug delivery platform for cancer therapy
Nowadays, Nano-sized drug delivery systems have been studied extensively for theirpotential in cancer therapy. Various drug nanocarriers are being developed including liposomes, micelles, and Virus like nanoparticles (VLNPs). VLNPs offer many advantages for developing smart drug delivery systems due to their precise and repeated structures and relatively large cargo capacities. Truncated ...
متن کاملGold nanoparticles as cancer theranostic agents
The application of nanotechnology in medicine involves using nanomaterials to develop novel therapeutic and diagnostic modalities. Given the unique physiochemical and optical properties of gold nanoparticle (GNP) such as good biocompatibility, nontoxic nature, surface properties and comparative stability, it has been widely studied in medicine, especially as a cancer theranostic agent. Th...
متن کامل