Inhibition of lymphocyte transformation by disrupted murine oncornavirus.
نویسندگان
چکیده
Freeze-thaw preparations of banded Rauscher murine leukemia virus markedly suppressed the in vitro cellular-mediated blastogenic response of murine splenic lymphocytes to phytohemagglutinin-P and to allogeneic cells in two-way mixed-leukocyte reaction. Suppression was shown not to be due to cytotoxicity or to virus-mitogen binding. It is suggested that a virion envelope component interferes with cellular-mediated immunity by altering cell recognition sites.
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ورودعنوان ژورنال:
- Cancer research
دوره 37 12 شماره
صفحات -
تاریخ انتشار 1977