Prognostic Value of Postoperative and Post-ablative Serum Thyroglobulin Levels in Patients with Differentiated Thyroid Cancer 'Rael

Background: The study was designed to examine the value of post-operative and post-ablative serum . thyroglobulin levels and diagnostic whole body scan in predicting remission in patients with differentiated thyroid carcinoma. Methodotogy: Serum TG levels and diagnostic iodine123 wIlole body scans performed prior to and 6-12 months after IlII ablation for ore were evaluated in 100 consecutive patients at King Faisal Specialist Hospital Riyadh. Patients were followed up for a period of 7.6 years (range 7-10 years). All patients underwent total thyroidectomy priorto III( ablation. Resutts: Patients with serum TG levels < 8 nglml post thyroidectomy (50 patients) also maintained low TG < 8 nglmt affer "'t ablation and had beffer outcome (1JO'l') remission. On the other hand OTe·subjects wffh higher TG > 8 nglml post thyroidectomy (50 palients) 40% remalneel in remission X' = 4.00, P = 0.046. For the group with initial high past- 8 nglmt affer ablation. At the end of follow up, '"t-Was was pasaive in 4% and 10% of patients wah inffial TG < 8 nglml and TG > 8 nglml respectively; Y!