Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells.
نویسندگان
چکیده
منابع مشابه
Biosynthesis of lactacystin.
The biosynthesis of lactacystin, a new microbial metabolite which induces differentiation of neuroblastoma cells, was studied by the feeding experiments of various 13C-labeled compounds and NMR spectroscopic analysis. The feeding experiments showed that lactacystin consists of three containing gamma-lactam moiety arises by a condensation between methylmalonic semialdehyde and C alpha position o...
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lactacystin (1), a novel sulfur-containing y-lactam produced by a culture broth of Streptomyces sp. OM6519.2'3) Lactacystin induces neuritogenesis and causes a transient increase in the intracellular CAMP level in mouse neuroblastoma cell line Neuro 2A. We have established an economic and versatile total synthesis of 1 involving as key steps stereoselective hydroxymethylation and an asymmetrica...
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Cells sense and interpret mechanical cues, including cell-cell and cell-substrate interactions, in the microenvironment to collectively regulate various physiological functions. Understanding the influences of these mechanical factors on cell behavior is critical for fundamental cell biology and for the development of novel strategies in regenerative medicine. Here, we demonstrate plasma lithog...
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The neuronal growth-associated protein GAP-43 is expressed during axonal outgrowth and regeneration (for review, see Benowitz and Routtenberg, 1987). In the present study, we demonstrate that GAP-43 is constitutively expressed by NB2a/d1 neuroblastoma cells. The initial, most rapid outgrowth period of neuritogenesis [0-4 hr after dibutyryl adenosine 3',5'-cyclic monophosphate (dbcAMP) treatment...
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Retinoic acid (RA) induces the differentiation of many cell lines, including those derived from neuroblastoma. RA treatment of SH-SY5Y cells induces the appearance of functional Trk B and Trk C receptors. Acute stimulation of RA-predifferentiated SH-SY5Y cells with brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), or neurotrophin 4/5 (NT-4/5), but not nerve growth factor (NGF), i...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 44 1 شماره
صفحات -
تاریخ انتشار 1991