Involvement of Methysergide-sensitive 5-ht Receptor in Pudendal Nerve Inhibition of Nociceptive and Non-nociceptive Bladder Activity in Cats
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چکیده
Hypothesis / aims of study Understanding the neurotransmitter mechanisms involved in pudendal nerve inhibition of bladder activity could lead to identify new pharmacological targets for overactive bladder. Currently little is known about the effect of 5-hydroxytryptamine (5-HT) 2 receptor on micturition reflex. This study used methysergide, a non-specific 5-HT2 receptor antagonist, and naloxone, an opioid receptor antagonist, to examine the involvement of these receptors in the inhibition of micturition reflex induced by pudendal nerve stimulation (PNS).
منابع مشابه
Sympathetic β-adrenergic mechanism in pudendal inhibition of nociceptive and non-nociceptive reflex bladder activity.
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