Dynamic Compression of Articular Cartilage Augments Interstitial Transport of a Glucose Analog

INTRODUCTION: Interstitial solute transport is essential for cellular activities in avascular articular cartilage. Increased solute transport via fluid convection has been proposed as a mechanism by which dynamic loading increases cell metabolism in cartilage explants; this may have application in mechanical conditioning of engineered cartilage constructs. However, optimal loading conditions have not been determined for specific solutes. The goal of this study was to determine effects of radially unconfined dynamic compression over a range of frequencies and amplitudes on desorption of a D-glucose analog from cartilage explant disks. Results may aid in understanding of cartilage physiology and targeted delivery of bioactive substances.