Epstein-Barr Virus-Induced Hemophagocytic Lymphohistiocytosis
نویسندگان
چکیده
Hemophagocytic lymphohistiocytosis (HLH) is one of the complications of Epstein-Barr virus (EBV) infection. Although the patients who have developed HLH following EBV have normal immune system, there are a few patients with EBV-induced immune deficiency who develop HLH as well. Here, we describe the case of a 10-year-old girl with neurological complications caused by EBV-induced HLH. The patient received rituximab, leading to weakening inflammation associated with EBV infection and suppression of disease through quick treatment.
منابع مشابه
Poor outcomes of chronic active Epstein-Barr virus infection and hemophagocytic lymphohistiocytosis in non-Japanese adult patients.
Chronic active Epstein-Barr virus infection manifests as a combination of persistent infectious mononucleosis-like symptoms and high viral load in apparently immunocompetent patients. It is closely related to Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. These 2 abnormal Epstein-Barr virus-associated diseases are seldom reported in individuals other than Japanese children an...
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Epstein-Barr virus (EBV) is a ubiquitous virus that infects nearly all people worldwide without serious sequela. However, for patients who have genetic diseases which predispose them to the development of hemophagocytic lymphohistiocytosis (HLH), EBV infection is a life-threatening problem. As a part of a themed collection of articles on EBV infection and human primary immune deficiencies, we w...
متن کاملAbbreviations: BM: bone marrow, CAEBV: chronic active Epstein-Barr virus infection, EBV: Epstein-Barr virus, EBER: Epstein-Barr virus-encoded mRNA, EBNA: Epstein-Barr virus-nuclear antigen, HLH: hemophagocytic lymphohistiocytosis, HIV: human immunodeficiency virus, HMB: hypersensitivity to mosquito
Affiliations: 1. Department of Pediatrics, 2. Department of Medicine and Biosystemic Science, 3. Department of Medicine, and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 4. Department of Infectious Diseases, National Research Institute for Child Health and Development, Tokyo, 5. Department of 2 Pathology, Faculty of Medicine, Kurume University School o...
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INTRODUCTION Hemophagocytic lymphohistiocytosis is characterized by multisystem inflammation, resulting from prolonged and intense activation of macrophages, histiocytes and CD8+ T-cells. Due to its variable presentation and non-specific findings, timely diagnosis can be challenging. This condition has been associated with malignancies, most commonly with lymphomas and leukemias of T-cell linea...
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