The Timeless Way of Building

The Timeless Way of Building REA Enterprise Systems

TIMELESS Forms a Complex with PARP1 Distinct from Its Complex with TIPIN and Plays a Role in the DNA Damage Response

PARP1 is the main sensor of single- and double-strand breaks in DNA and, in building chains of poly(ADP-ribose), promotes the recruitment of many downstream signaling and effector proteins involved in the DNA damage response (DDR). We show a robust physical interaction between PARP1 and the replication fork protein TIMELESS, distinct from the known TIMELESS-TIPIN complex, which activates the in...

No Way out 1 the Timeless Trap

Evolving a Patterns Culture

The foundation for the work in using and writing patterns began with Christopher Alexander who wrote such publications as A Timeless Way of Building and A Pattern Language in the 1970s. When software developers began studying his ideas, interest in patterns began to spread throughout the software development industry in the 1990s. However, efforts to introduce patterns into organizations have h...

How Architecture is Conceived, the Case of Fondazione Feltrinelli Building in Milan

Architecture lays on the intersection between art and science. However, while the social effects of architecture are coming to the fore, there emerges to be a notion that technological progress in the construction sector demands more scientifically inclined research in the field. This notion can not be segregated from the technical aspect and it is through this notion that architecture can be c...