Compromised frontal callosal connectivity in unmedicated obsessive-compulsive disorder: a quantitative diffusion tractography study
نویسندگان
چکیده
J. S. Oh, J. Jang, W. Jung, C-H. Choi, J-S. Choi, D-H. Kang, and J. Kwon Brain Korea 21 Division of Human Life Science, Seoul National University, Seoul, Seoul, Korea, Republic of, Psychiatry, Seoul National University College of Medicine, Seoul, Seoul, Korea, Republic of, Interdisciplinary Program in Brain Science, Seoul National University, Seoul, Seoul, Korea, Republic of, Radiology, National Medical Center, Seoul, Seoul, Korea, Republic of, Neuropsychiatry, Seoul National University Hospital, Seoul, Seoul, Korea, Republic of
منابع مشابه
Hyperactive error responses and altered connectivity in ventromedial and frontoinsular cortices in obsessive-compulsive disorder.
BACKGROUND Patients with obsessive-compulsive disorder (OCD) show abnormal functioning in ventral frontal brain regions involved in emotional/motivational processes, including anterior insula/frontal operculum (aI/fO) and ventromedial frontal cortex (VMPFC). While OCD has been associated with an increased neural response to errors, the influence of motivational factors on this effect remains po...
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Fronto-striatal circuits are hypothesized to be involved in the pathophysiology of obsessive-compulsive disorder (OCD). Within this circuitry, ventral frontal regions project fibers to the ventral striatum (VS) and dorsal frontal regions to the dorsal striatum. Resting state fMRI research has shown higher functional connectivity between the orbitofrontal cortex (OFC) and the dorsal part of the ...
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BACKGROUND Obsessive-compulsive disorder (OCD) is characterized by an excessive focus on upsetting or disturbing thoughts, feelings, and images that are internally-generated. Internally-focused thought processes are subserved by the "default mode network" (DMN), which has been found to be hyperactive in OCD during cognitive tasks. In healthy individuals, disengagement from internally-focused th...
متن کاملAltered Brain Activation in Ventral Frontal-Striatal Regions Following a 16-week Pharmacotherapy in Unmedicated Obsessive-Compulsive Disorder
Recent studies have reported that cognitive inflexibility associated with impairments in a frontal-striatal circuit and parietal region is a core cognitive deficit of obsessive-compulsive disorder (OCD). However, few studies have examined progressive changes in these regions following clinical improvement in obsessive-compulsive symptoms. To determine if treatment changes the aberrant activatio...
متن کاملReduced functional connectivity within the limbic cortico-striato-thalamo-cortical loop in unmedicated adults with obsessive-compulsive disorder.
Cortico-striato-thalamo-cortical (CSTC) loops project from the cortex to the striatum, then from the striatum to the thalamus via the globus pallidus, and finally from the thalamus back to the cortex again. These loops have been implicated in Obsessive-Compulsive Disorder (OCD) with particular focus on the limbic CSTC loop, which encompasses the orbitofrontal and anterior cingulate cortices, as...
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