[Melanoma and retinoblastoma].

Actas Dermosifiliogr. 2009;100:615-34 624 the etiology of the calcification. Clinical manifestations will also depend on the underlying disorder (if present), but usually there are multiple, hard, whitish papules, plaques, or nodules with a symmetrical distribution. Morbidity depends on the extent and site of the cutaneius calcification; joints, muscles, and organs such as the lungs, kidneys, and intestine may also be affected. In addition, vascular deposits of calcium can give rise to distal ischemia and necrosis. Areas of ulceration or the transcutaneous elimination of a whitish-yellow, chalklike matreial may be observed, and secondary infection can develop. The therapeutic measures used depend on the underlying disease; in general the outcomes are not very satisfactory and only the results of case reports are available. Most medical treatments for calcinosis cutis have been described in patients with connective tissue diseases. They include warfarin, colchicine, probenecid, bisphosphonates, minocycline, and diltiazem.4-8 Success has also been reported with other treatment modalities, such as carbon dioxide laser and intralesional corticosteroid injection.9,10 Finally, surgery is a possible option to remove calcium deposits in necrotic or infected tissues. In conclusion, calcinosis cutis is a rarely reported sequela of acne and represents a therapeutic challenge. Clinical suspicion and appropriate additional tests are required to reach the diagnosis.