Early Preventive Effects of Risedronate in a Rat Model with Massive Bone Loss Due to Orchidectomy and Localized Disuse
نویسندگان
چکیده
Short running title: Bone loss due to orchidectomy and localized disuse.ABSTRACT Alterations on lean, fat mass, bone mass and archtitecture were maximized on the paralysed side of a model combining orchidectomy and hindlimb paralysis induced by botulinum neurotoxin. Risedronate have protective effects on tabecular bone but failed to preserve cortical bone on the paralysed side.
منابع مشابه
Effects of risedronate in a rat model of osteopenia due to orchidectomy and disuse: densitometric, histomorphometric and microtomographic studies.
Dual energy X-ray absorptiometry (DXA), histomorphometry and X-ray microtomography (microCT) were used to assess effects of risedronate and testosterone in a combined rat model of orchidectomy (ORX) and local paralysis induced by botulinum neurotoxin (BTX). Four groups of mature rats were studied for 1 month: SHAM operated; ORX and right hindlimb immobilization (BTX); ORX+BTX+risedronate or tes...
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