The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II.
نویسندگان
چکیده
Lasso peptides are fascinating natural products with a unique structural fold that can exhibit tremendous thermal stability. Here, we investigate factors responsible for the thermal stability of caulosegnin II. By employing X-ray crystallography, mutational analysis and molecular dynamics simulations, the ring residue proline 8 was proven to be crucial for thermal stability.
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ورودعنوان ژورنال:
- Molecular bioSystems
دوره 12 4 شماره
صفحات -
تاریخ انتشار 2016