The Wittig Reaction
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منابع مشابه
An Efficient One-pot Synthesis of Dialkyl fumarates Mediated by inyltriphenylphosphonium Salt in the Intramolecular Wittig Reaction
An efficient three-component reaction of dialkyl acetylendicarboxylates and 2-Pyrrolidin in the presence of triphenylphosphine produces dialkyl 2-(2-Pyrrolidin-N-yl)-3-(triphenylphosphanylidene)succinate. These phosphoranes undergo mild intramolecular Wittig reaction to produce dialkyl (E)-2-(4,5-dihydro-3H-pyrrol-2-yl)fumarate in excellent yields.
متن کاملAPPLICATION OF MICROWAVE IRRADIATION TECHNIQUES FOR THE WITTING REACTION
The Wittig reaction rate can be dramatically enhanced by irradiation of the reaction mixture containing an aldehyde or ketone; methoxymethyl(triphenyl)phosphonium chloride, potassium t-butoxide, and t BuOH with a commercial microwave oven. Carbonyl compound are converted to Witting products within three min. in good yields.
متن کاملThe Wittig Reaction
This so-called Wittig reaction has a number of advantages over other olefination methods; in particular, it occurs with total positional selectivity (that is, an alkene always directly replaces a carbonyl group). By comparison, a number of other carbonyl olefination reactions often occur with double-bond rearrangement. In addition, the factors that influence Eand Z-stereoselectivity are well un...
متن کاملA Facile One-Pot Synthesis of Functionalized N-Hydroxypyrrole Mediated by Vinyl-Triphenylphosphonium Salt
Protonation of the reactive intermediates generated in the raction between dalkyl acetylenedicarboxylates and triphenylphosphine by isonitrosoacetophenone leads to vinyltriphenylphosphonium salts, which undergo intramolecular Wittig reaction to produce dalkyl 4-phenyl-N-hydroxypyrrole-2,3-dicarboxylates in moderate yields.
متن کاملUsing the Wittig reaction to produce alkenylcarbaboranes.
This communication reports the first use of the Wittig reaction to produce alkenylcarbaboranes.
متن کاملSynthesis and decarboxylative Wittig reaction of difluoromethylene phosphobetaine.
A key intermediate, difluoromethylene phosphobetaine, in the Wittig reaction of ClCF2CO2Na-Ph3P with aldehydes was synthesized and characterized, which confirmed the reaction mechanism. The decarboxylation of this stable intermediate was a convenient approach for Wittig difluroolefination. Its reactivity could be adjusted by the modification of the substituent on the phosphorus.
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