Papilloma formation in the forestomach of the mouse following oral administration of urethan (ethyl carbamate).
نویسندگان
چکیده
fails to respond to the action of carcinogenic hy drocarbons when administered from within the lumen (see reviews 1, 6, 7, 12). Such carcinogens are known to induce tumors of glandular mucosa when injected into the submucosa (4, 5, 11) but induce only tumors of the squamous epithelium of the forestomach when administered by mouth (2, 8, 10). On the assumption that the "mucus barrier" (6) might prevent water-insoluble car
منابع مشابه
In vivo tests for a carcinogenic metabolite in plasma of animals given injections of ethyl carbamate (urethan).
Plasma, obtained from rabbits given injections of urethan 2J hours previously, when administered intraperitoneally to Swiss mice, produced a significantly increased inci dence of lung adenomas in these animals, as well as an increased incidence of skin papillomas at the site of subsequent croton oil applications. These effects were not obtained when the plasma was lyophilized or desiccated, wit...
متن کاملUrethan Carcinogeiiesis and Nucleic Acid Metabolism: Factors Influencing Lung Adenoma Induction1
Experiments were performed (a) to test the validity of the proposal that urethan (ethyl carbamate) acts by virtue of its conversion to Ar-hydroxyurethan, and (6) to examine the general ity of the reported observations that pyrimidines interfere with lung adenoma formation by urethan. Conditions were obtained in adult and newborn SWR mice in which the average number of tumors per mouse increased...
متن کاملComparative carcinogenicities and mutagenicities of vinyl carbamate, ethyl carbamate, and ethyl N-hydroxycarbamate.
Structural modifications of the multipotential carcinogen ethyl carbamate (urethan), CH3CH2—O---CO—-NH2, generally result in dramatic losses of carcinogenic activity, which usually have been assayed by lung adenoma induction and by initiation of skin papillomas in mice (reviewed in Refs. 12 and 20). One exception is ethyl N-hydroxycanbamate, CH3CH2— O—CO—-NHOH, a metabolite of ethyl c...
متن کاملNeoplastic response of various tissues to the administration of urethan.
Investigations on the multipotential carcinogenicity of urethan (ethyl carbamate) in mice have been extended by a series of three experiments in which the agent was administered in drinking water. Fifty-three-week-old DBA and 5-week-old CSH inbred mice were permitted to drink either 0.1 per cent or 0.3 per cent solutions and were kept on the respective treatments for periods ranging from 6@to 3...
متن کاملUrethan and leukemogenesis in mice.
other respects. It induces pulmonary tumors in rodents (10, 11); when administered orally to mice, papillomas of the forestomach may appear (1). Urethan initiates skin carcinogenesis in mice, although when administered alone skin tumors do not appear (14). Hemangiomas of the mouse liver have been induced by this chemical (6). The objective of this investigation was to test the influence of this...
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ورودعنوان ژورنال:
- Cancer research
دوره 17 4 شماره
صفحات -
تاریخ انتشار 1957