บทความที ่ น่ าสนใจประจ าเดื อน สิ งหาคม 2556 Title : Calcineurin Expression and Localisation during Porcine Oocyte Growth and Meiotic Maturation Title : Combined Hepatocellular and Cholangiocarcinoma (biphenotypic) Tumors: Imaging Features and Diagnostic Accuracy of Contrast-enhanced Ct and Mri

The processes of oocyte growth, acquisition of meiotic competence and meiotic maturation are regulated by a large number of molecules. One of them could be calcineurin consisting of catalytic subunit A (Aα, Aβ, Aγ isoforms) and regulatory subunit B (B1, B2 isoforms). Calcineurin is involved in the meiotic maturation of oocytes in invertebrates or in lower vertebrates. In the mammalian oocytes, the possible role of calcineurin in the regulation of oocyte meiosis has not been clarified to date. In this study, to investigate the role of calcineurin during porcine oocyte growth, acquisition of meiotic competence and meiotic maturation, we analysed the expression and localisation of calcineurin subunits and the mRNA expression of calcineurin isoforms. Calcineurin was expressed in growing porcine oocytes, in fully-grown oocytes and during their in vitro meiotic maturation. We found both subunits of calcineurin. Calcineurin A and calcineurin B were localised mainly in cortex in all porcine oocytes. The changes in the intracellular localisation of separate calcineurin subunits during meiotic maturation were determined. We detected mRNA for calcineurin isoforms Aβ, Aγ, B2 in oocytes and mRNA for calcineurin isoforms Aβ, Aγ, B1, and B2 in cumular cells. To our knowledge, this is the first confirmation of calcineurin presence in porcine oocytes. Database : ScienceDirect Title : Combined Hepatocellular and Cholangiocarcinoma (Biphenotypic) Tumors: Imaging Features and Diagnostic Accuracy of Contrast-Enhanced CT and MRI Author : Kathryn J. Fowler, Arman Sheybani, Rex A. Parker III, Sean Doherty, Elizabeth M. Brunt, William C. Chapman, Christine O. Menias Journal : American Journal of Roentgenology: August 2013, Volume 201, Number 2, p 332339 Abstract : The purpose of this study was to evaluate the diagnostic accuracy of preoperative imaging for diagnosis of combined hepatocellular cholangiocarcinoma tumors and to evaluate the clinical and imaging features and demographics of patients presenting to our institution with such tumors. The purpose of this study was to evaluate the diagnostic accuracy of preoperative imaging for diagnosis of combined hepatocellular cholangiocarcinoma tumors and to evaluate the clinical and imaging features and demographics of patients presenting to our institution with such tumors. Database : Free Medical Journals Title : A Radiologist's Guide to Treatment Response Criteria in Oncologic Imaging: Functional, Molecular, and Disease-Specific Imaging Biomarkers Author : Pedram Rezai, Mark J. Pisaneschi, Chun Feng and Vahid Yaghmai Journal : American Journal of Roentgenology: August 2013, Vol. 201, Number 2, p 246-256 Abstract : This article reviews the functional, molecular, and disease-specific imaging biomarkers of treatment response. This article reviews the functional, molecular, and disease-specific imaging biomarkers of treatment response. Database : Free Medical Journals Title : Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids (pages 1378–1389) Author : 1. Susanna L. Lundström, Jun Yang, John D. Brannan, Jesper Z. Haeggström, Bruce D.