Tumor-specific transplantation antigens: G. H. A. Clowes memorial lecture.

Viral etiology of cancer and leukemia: a look into the past, present and future--G.H.A. Clowes Memorial Lecture.

Regulation of the p53 protein by the MDM2 oncoprotein--thirty-eighth G.H.A. Clowes Memorial Award Lecture.

Preface It was, indeed, a wonderful honor to receive the G. H. A. Clowes Memorial Award and present the Clowes Lecture at the Meeting for the American Association for Cancer Research. I have been fortunate to carry out research in the area of cancer biology at a remarkable time and to have had many truly extraordinary colleagues in this field. When I began my graduate student research in 1961, ...

On the origin of the genes for neoplasia: G.H.A. Clowes memorial lecture.

Chart 1. The origin of the genes for cancer. A cancer cell has in its DNA (zigzag line) genes for cancer (oval). virions contain RNA and a DNA polymerase. I shall particularly deal with the two groups of avian ribodeoxy viruses, the avian leukosis-sarcoma viruses and the reticulo endotheliosis viruses. I shall then present our current ideas about the origin of these ribodeoxyviruses and indicat...

Expression of various tumor-specific antigens in polyoma virus-induced tumors.

I h e qu a n t i t ative expression of tumor-specific transplantation antigen, tumor-specific cell surface antigen, and T-antigen in polyoma virus-induced tumors was studied. A mouse polyoma virus-transformed cell line (4198) and its variant line (4198V) were both shown to possess polyoma tumor-specific transplantation antigen, but the variant line was more immunosensitive. The 4198V cells had ...

Biochemical strategy of cancer cells and the design of chemotherapy: G. H. A. Clowes Memorial Lecture.

An understanding of the biochemical strategy of the cancer cell is the via regia for the design of enzyme pattern-directed anticancer chemotherapy. The development and impact of novel approaches that provided us with paradigms for problem solving in these two central areas of cancer research will be emphasized in this presentation. I will underline the essence and substance of our conceptual an...