Myriocin as an atherosclerosis inhibitor
نویسنده
چکیده
Brett Garner Prince of Wales Medical Research Institute, Randwick NSW 2031, Australia and, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney NSW 2052, Australia Tel.: +61 293 991 024; Fax: +61 293 991 005; [email protected] ‘It appears quite possible that detailed investigations of the antiatherogenic actions of myriocin will reveal therapeutic targets that can be more selectively regulated in the future.’
منابع مشابه
Myriocin-mediated up-regulation of hepatocyte apoA-I synthesis is associated with ERK inhibition
Sphingolipids including sphingomyelin have been implicated as potential atherogenic lipids. Studies in apoE (apolipoprotein E)-null mice have revealed that the serine palmitoyltransferase inhibitor myriocin reduces plasma levels of sphingomyelin, ceramide, sphingosine-1-phosphate and glycosphingolipids and that this is associated with potent inhibition of atherosclerosis. Interestingly, hepatic...
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The serine palmitoyl transferase inhibitor myriocin potently suppresses the development of atherosclerosis in apolipoprotein E (apoE) gene knockout (apoE(-/-)) mice fed a high-fat diet. This is associated with reduced plasma sphingomyelin (SM) and glycosphingolipid levels. Furthermore, oral administration of myriocin decreases plasma cholesterol and triglyceride (TG) levels. Here, we aimed to d...
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متن کاملInhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice.
BACKGROUND In clinical studies, sphingomyelin (SM) plasma levels correlated with the occurrence of coronary heart disease independently of plasma cholesterol levels. We hypothesized that inhibition of SM synthesis would have antiatherogenic effects. To test this hypothesis, apolipoprotein E (apoE)-knockout (KO) mice were treated with myriocin, a potent inhibitor of serine palmitoyltransferase, ...
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Glycosphingolipids (GSLs) have been implicated as potential atherogenic lipids. Studies in apolipoprotein E-null (apoE(-/-)) mice indicate that exacerbated tissue GSL accumulation resulting from alpha-galactosidase deficiency promotes atherosclerosis, whereas the serine palmitoyl transferase inhibitor myriocin (which reduces plasma and tissue levels of several sphingolipids, including sphingomy...
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