Meeting Report The biological basis for antiangiogenic therapy
نویسندگان
چکیده
Mario Negri Institute for Pharmacological Research, Via Gavazzeni 11, Bergamo, Italy National Institute for Cancer Research, Genoa, Italy Institute for Cancer Research and Treatment, University of Turin, Italy European Institute of Oncology, Milan, Italy Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy University of Siena, Italy European School of Oncology, Milan, Italy
منابع مشابه
Cyclin-dependent kinase 5 regulates endothelial cell migration and angiogenesis.
Angiogenesis contributes to various pathological conditions. Due to the resistance against existing antiangiogenic therapy, an urgent need exists to understand the molecular basis of vessel growth and to identify new targets for antiangiogenic therapy. Here we show that cyclin-dependent kinase 5 (Cdk5), an important modulator of neuronal processes, regulates endothelial cell migration and angio...
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Pigment epithelium-derived factor (PEDF) is a glycoprotein that belongs to the family of non-inhibitory serpins. The broad spectrum of PEDF biological activity is evident when considering its effects in promoting cell survival and proliferation, as well as its antiangiogenic, antitumor, and anti-metastatic properties. Although the structural domains of the PEDF gene that mediate such diverse ef...
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Background: Despite advances in cancer diagnosis and treatment, survival rate of patients suffering from glioblastoma multiform (GBM) has not been significantly improved. Therefore, novel therapeutic adjuncts to routine therapies have been suggested over time. Inhibition of angiogenesis by antiangiogenic drugs is one of the new approaches to inhibit the growth of malignant cells. Microvessel d...
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We thank Ciccolini et al. (1) for their interest in our report (2) on a clinical study, published recently in PNAS. In that paper, we report that improved tumor vascular function after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in non-small cell lung cancer (NSCLC) patients. We also suggest that imaging and circulating markers of vascular normalization could ...
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Renal cell carcinoma (RCC) is an immunogenic and proangiogenic cancer, and antiangiogenic therapy is the current mainstay of treatment. Patients with RCC develop innate or adaptive resistance to antiangiogenic therapy. There is a need to identify biomarkers that predict therapeutic resistance and guide combination therapy. We assessed the interaction between antiangiogenic therapy and the tumor...
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