Affective psychosis following Accutane (isotretinoin) treatment.

Accutane (isotretinoin) and psychiatric adverse effects.

Subacromial/subdeltoid septic bursitis associated with isotretinoin therapy and corticosteroid injection.

Subacromial septic bursitis after corticosteroid injection is exceedingly rare. This report describes a case of Staphylococcus aureus subacromial septic bursitis after corticosteroid injection in a patient undergoing isotretinoin (Accutane) therapy. This case is only the third reported in the literature linking a corticosteroid injection with septic subacromial bursitis and the first to describ...

Isotretinoin (Accutane) as a Teratogen

Isotretinoin is a molecule and a byproduct (metabolite) of vitamin A, and in greater than normal amounts in pregnant women, it can cause fetal abnormalities including cleft lips, ear and eye defects, and mental retardation [5]. Isotretinoin is commonly called by its trade name Accutane, and it's a chemical compound derived from vitamin A, also called retinoic acid. Doctors prescribe isotretinoi...

Executive Summary: Clinical

Accutane “NF” is a new formulation of isotretinoin, a drug substance that was approved in 1982. The indication remains severe recalcitrant nodular acne. The Sponsor’s stated reason for pursuing this new formulation is that improved bioavailability will allow once daily dosing with or without food, as opposed to twice daily with food as per labeling for the current Accutane® formulation. The Spo...

Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration.

Recessive Stargardt's macular degeneration is an inherited blinding disease of children caused by mutations in the ABCR gene. The primary pathologic defect in Stargardt's disease is accumulation of toxic lipofuscin pigments such as N-retinylidene-N-retinylethanolamine (A2E) in cells of the retinal pigment epithelium. This accumulation appears to be responsible for the photoreceptor death and se...