Silicon-[F]Fluorine Radiochemistry: Basics, Applications and Challenges
نویسندگان
چکیده
Silicon-[F]fluorine (Si-F) radiochemistry has recently emerged alongside other unconventional approaches such as aluminum-F and boron-F based labeling strategies, reshaping the landscape of modern F-radiochemistry. All these novel methodologies are driven by the demand for more convenient F-labeling procedures to further disseminate one of the most sophisticated imaging technologies, Positron Emission Tomography (PET). The PET methodology requires special radionuclides such as F (one of the most prominent examples) to be introduced into bioactive molecules. Si-F radiochemistry contributed greatly towards the development of new radiopharmaceuticals for PET imaging. Herein, we describe the radiochemical basics of Si-F bond formation, the application of Si-F tracers for PET imaging, and additionally, the inherent chemical intricacies of this methodology. OPEN ACCESS Appl. Sci. 2012, 2 278
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