Mutation-Drift Balance
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On the distribution of the mean and variance of a quantitative trait under mutation-selection-drift balance.
The distributions of the mean phenotype and of the genetic variance of a polygenic trait under a balance between mutation, stabilizing selection and genetic drift are investigated. This is done by stochastic simulations in which each individual and each gene are represented. The results are compared with theoretical predictions. Some aspects of the existing theories for the evolution of quantit...
متن کاملCompensatory Drift and the Evolutionary Dynamics of Dosage-Sensitive Duplicate Genes.
Dosage-balance selection preserves functionally redundant duplicates (paralogs) at the optimum for their combined expression. Here we present a model of the dynamics of duplicate genes coevolving under dosage-balance selection. We call this the compensatory drift model. Results show that even when strong dosage-balance selection constrains total expression to the optimum, expression of each dup...
متن کاملAssociation mapping reveals the role of mutation-selection balance in the maintenance of genomic variation for gene expression
The evolutionary forces that maintain genetic variation for quantitative traits within populations remain poorly understood. One hypothesis suggests that variation is maintained by a balance between new mutations and their removal by selection and drift. Theory predicts that this mutation-selection balance will result in an excess of low-frequency variants and a negative correlation between min...
متن کاملEvolution of Drift Robustness in Small Populations of Digital Organisms
Most mutations are deleterious and cause a reduction in population mean fitness known as the mutational load. In small populations, weakened selection against slightly-deleterious mutations results in an additional reduction in fitness: the drift load. Many studies have established that populations can evolve a reduced mutational load by evolving mutational robustness, but it is uncertain wheth...
متن کاملHeterogeneity in Synonymous Codon Usage among Genes of Diverse Bacterial Genomes
It has become clear that in most bacterial species there is considerable heterogeneity in codon usage among genes, and the codon usage of any gene is thought to reflect a balance between the forces of mutation, selection, and random genetic drift [4]. The strength and direction of these forces vary for different species, depending on their lifestyles [1]. In this study, we investigated the leve...
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تاریخ انتشار 2015