Equine Herpesvirus Type 1 (EHV-1) pUL56 Promotes Dynamin-dependent Endocytosis and Cooperates with pUL43 for Downregulation of Cell Surface MHC class I
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Identification and characterization of equine herpesvirus type 1 pUL56 and its role in virus-induced downregulation of major histocompatibility complex class I.
Major histocompatibility complex class I (MHC-I) molecules play an important role in host immunity to infection by presenting antigenic peptides to cytotoxic T lymphocytes (CTLs), which recognize and destroy virus-infected cells. Members of the Herpesviridae have developed multiple mechanisms to avoid CTL recognition by virtue of downregulation of MHC-I on the cell surface. We report here on an...
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19 Major histocompatibility complex class I (MHC-I) molecules play an important role in host 20 immunity to infection by presenting antigenic peptides to cytotoxic T lymphocytes (CTL), which 21 recognize and destroy virus-infected cells. Members of Herpesviridae have developed multiple 22 mechanisms to avoid CTL recognition by virtue of downregulation of MHC-I on the cell surface. 23 We report ...
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