Asymmetric Synthesis of 1,2-dioxanes: Approaches to the Peroxyplakoric Acids.
نویسندگان
چکیده
The stereospecific intramolecular alkylation of a hydroperoxyacetal provides the basis for the first asymmetric synthesis of the dioxane propionate core of the peroxyplakorates. Chemoselective hydrometallation of an alkyne in the presence of a peroxide is used to introduce a synthon for the polyunsaturated side chains of the peroxyplakorates. The route suggests a general solution for the 1,2-dioxane unit in many peroxide natural products.
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ورودعنوان ژورنال:
- Tetrahedron
دوره 65 47 شماره
صفحات -
تاریخ انتشار 2009