Pharmaceutical Utility of Assam Bora Rice for Controlled Drug Delivery

نویسندگان

  • Nikhil K. Sachan
  • S. K. Ghosh
  • A. Bhattacharya
چکیده

The use of natural polymers in the drug delivery continues to be an area of intensive research despite the advent of several new synthetic polymers. The present study envisages pharmaceutical utility of Assam glutinous rice as natural biopolymeric matrix for microfabricated controlled DDS. Microcarriers were prepared using an industrially feasible ionic gelation method using the blends of proposed new biopolymer alongwith sodium alginate. The microcarriers so prepared were subjected to characterization for particle size analysis, entrapment efficiency, mucoadhesivity, swelling, surface topography and drug release kinetics in an in vitro dissolution testing. The prepared microcarriers showed excellent drug entrapment efficiency, having the particle size distribution in range of 0.98 ± 0.008 to 1.12 ± 0.014 mm and exhibited pH dependent drug release in an in vitro dissolution test. Scanning electron microscopy revealed the irregular surface of the microcarriers and with varying shapes.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Formulation, evaluation and optimization of pectin- bora rice beads for colon targeted drug delivery system.

PURPOSE The purpose of this research was to established new polysaccharide for the colon targeted drug delivery system, its formulation and in vitro and in vivo evaluation. METHODS Microspheres containing pectin and bora rice were prepared by ionotropic gelation technique using zinc acetate as cross linking agent and model drug used was glipizide. A 3(2) full factorial design was employed to ...

متن کامل

Assam Bora Rice Starch as Directly Compressible Filler- Binder

Introduction: Northeast India, including Assam, is recognized as a centre of origin of rice and is

متن کامل

Formulation, Evaluation and Optimization of Controlled Release Hydrogel Microspheres for Colon Targeted Drug Delivery

The purpose of this research was to established new polysaccharide for the colon targeted drug delivery system, its formulation and in vitro and in vivo evaluation. Microspheres containing chitosan and bora rice were prepared by simple emulsification phase separation technique using glutaraldehyde as cross linking agent and model drug used was glipizide. Results of trial batches indicated that ...

متن کامل

Matrix Tablets: An Effective Way for Oral Controlled Release Drug Delivery

       The purpose of this review article is to characterize all of the parameters regarding the types, polymers used, and release kinetics of matrix tablets. Matrix system was the earliest oral extended release platform for medicinal use. Matrix tablets are most commonly used methods to modulate the release profile of drugs. They are much desirable and preferred for such therapy because they o...

متن کامل

Design and Evaluation of Ocular Controlled Delivery System for Diclofenac Sodium

Diclofenac sodium as ophthalmic dosage form is used in patients treatment of eye pain, swelling and redness recovering from cataract surgery but it faces the bioavailability limitation of eye drops due to effective protective mechanisms and corneal barrier functions in the eyes. Therefore, this investigation was aimed to develop ocular film formulations to achieve controlled drug release. Drug ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013